Scalable Magnetic Bead Separation for R&D and Pilot-Scale Production
From process development to pilot-scale production, Sepmag A delivers reliable, reproducible magnetic bead separation – with full scalability and real-time monitoring.
Precision Separation with Sepmag A
Whether you’re optimizing a protocol at the benchtop or transitioning to mid-scale production, Sepmag A R&D magnetic bead separators provide constant magnetophoretic conditions across the separation area – ensuring identical performance at any volume.
Scalability to use the same separation parameters from 1.5 ml tubes to 400 ml bottles
Validated and standardized protocols to transfer methods between teams, timepoints, and scales with confidence
High recovery and minimal loss to achieve high purity and yield – even with complex or viscous samples
Sepmag A200ml & A400ml
Sepmag A200ml and A400ml are purpose-built for high-volume magnetic bead separation workflows, offering consistent, scalable performance for process development, method validation, and pilot-scale production.
With precise magnetophoretic control across the entire separation area, both systems ensure that all magnetic beads – regardless of vessel size – are subjected to constantmagnetic force. This prevents aggregation, enhances reproducibility, and maintains separation efficiency across a wide range of volumes.
The Sepmag A200ml and A400ml systems are especially well-suited for teams developing standardized, transferable workflows where performance and consistency cannot be compromised, with researchers benefitting from high recovery rates and minimal sample loss to enable reliable scale-up from benchtop protocols to larger production formats.
Technical Information
Sepmag A200 ml | Sepmag A400 ml | |
Bottle Size | 250ml | 500ml |
Sample Volume | 100-200 ml | 200-400 ml |
Dimensions | Ø 176 mm × 80 mm | Ø 206 mm × 96 mm |
Caution Distances | Ø 315 mm x 250 mm | Ø 340 mm x 262 mm |
Weight | 4.2 kg | 5.7 kg |
Both Sepmag A200ml and A400ml systems support adaptors for small tubes, enabling protocol development and troubleshooting before committing to scale-up volumes.
Compatible Tube Sizes & Volumes | |
1.5 ml tubes | 0.5-1.5 ml |
2 ml tubes | 1-2 ml |
15 ml tubes | 4.5-9 ml |
50 ml tubes | 17.5-35 ml |
Core Benefits
The Sepmag A200ml and A400ml R&D magnetic bead separators are built on the same core design principles that ensure reliable, scalable magnetic bead separation. Both models support standardized, reproducible workflows at every stage, demonstrating the following benefits:
Scalable Separation
Maintain identical magnetic conditions from 1.5 ml to 400 ml
High Recovery, Low Loss
Efficiently isolate target biomolecules or cells with minimal waste
Constant Magnetic Force
The same conditions prevent clumping to ensure clean, reproducible separations
Real Time Monitoring
MONITOR software tracks bead movement, optimizes protocols, and validates performance.
Adaptable Format
Compatible with bottles and standard tube sizes via adaptors
Process Validation Ready
Standardize, document, and transfer workflows with confidence
Track, Understand, and Improve Every Separation with Sepmag MONITOR
Real-time monitoring. Quantifiable results. Reproducible science.
Sepmag MONITOR is our integrated software and hardware solution that gives you full visibility into the magnetic bead separation process. Instead of relying on assumptions or visual estimations, MONITOR provides real-time optical tracking of bead movement – turning every experiment into a data-rich process that can be analyzed, standardized, and optimized.
Featuring the key benefits:
Real-time tracking of magnetic bead migration using optical sensors
Quantitative measurement of separation dynamics for data-driven optimization
Reproducibility across runs, users, and protocols
Protocol validation and standardization across labs, sites, or team members
User-friendly software interface, with data export for further analysis
Integration with both A200ml and A400ml systems
Clients
Trusted by leading life science companies:
Questions & Answers
What are R&D magnetic bead separators?
R&D magnetic bead separators are systems designed for research, process development, and early production stages where magnetic bead–based workflows must be optimized, validated, and transferred to larger scales. They support reproducible magnetic bead separation while enabling direct scalability toward pilot and production environments.
How do Sepmag R&D separators support process development?
Sepmag R&D magnetic bead separators apply a constant magnetic force throughout the entire working volume, ensuring that all beads experience identical separation conditions. This allows scientists to develop, optimize, and validate protocols that remain stable and reproducible when transferred to small production or industrial scales.
Why is reproducibility critical in R&D and small production workflows?
In R&D and small production, variability directly impacts process robustness, validation timelines, and technology transfer. Sepmag systems eliminate separation variability by maintaining constant magnetic force, enabling consistent bead behavior, reliable yields, and repeatable results across runs and batches.
How do Sepmag separators simplify scale-up from R&D to production?
Sepmag technology enables true scale-up without process redesign. Because the separation conditions remain constant across volumes and systems, protocols developed during R&D can be transferred to small production and later to large-volume manufacturing without re-optimization or revalidation.
What types of applications benefit from Sepmag R&D magnetic bead separators?
Sepmag R&D systems are widely used in:
- Nucleic acid extraction and purification
- Protein capture and purification
- Cell isolation workflows
- Diagnostic assay development
- Process development for biomanufacturing and reagent production
These applications benefit from controlled, reproducible magnetic bead separation during method development and early production.
What is the role of real-time monitoring in Sepmag R&D separators?
Sepmag R&D systems integrate real-time monitoring to quantify and track separation performance during development. This allows teams to objectively compare protocols, identify deviations, document performance, and generate traceable data to support validation, quality assurance, and technology transfer.
How do Sepmag systems reduce risk during process validation?
By delivering stable and reproducible separation conditions, Sepmag separators reduce batch-to-batch variability and minimize unexpected failures during validation. This lowers technical risk, accelerates development timelines, and improves confidence when moving from R&D to small production.
Are Sepmag R&D separators suitable for regulated environments?
Yes. Sepmag systems are designed to support traceability, reproducibility, and process control—key requirements for regulated diagnostic and biomanufacturing environments. The ability to document separation performance strengthens compliance with quality and regulatory expectations.
What distinguishes Sepmag R&D separators from conventional magnetic solutions?
Unlike conventional systems that expose beads to non-uniform separation conditions, Sepmag separators apply a constant magnetic force across the entire volume. This prevents bead aggregation, improves recovery, and ensures that process performance is independent of vessel geometry or scale.
Why choose Sepmag for R&D and small production magnetic bead separation?
Customers choose Sepmag because it enables:
- Reproducible and scalable magnetic bead separation
- Reliable process development and validation
- Seamless transition from R&D to small production
- High recovery and consistent performance
- Reduced development time and operational risk
Sepmag provides a solid technological foundation for moving magnetic bead workflows from the lab to manufacturing.
Ready to Improve Your Magnetic Separation Workflow?
Sepmag A systems deliver the scalability, reproducibility, and real-time insight needed for confident process development and pilot-scale production.
Speak with our experts to find the right system for your workflow or request a demo to see Sepmag A in action.
