Large Volume Magnetic Bead Separators for GMP Manufacturing
Sepmag Q and Sepmag N are large volume magnetic bead separators designed for liter-scale production and GMP manufacturing.
Achieve high product recovery, reproducible batch-to-batch separation and objective process control with real-time monitoring included as a standard part of every system.
Choose Sepmag Q for glass vessels or Sepmag N for plastic and single-use vessels.
Choose the Right Sepmag System
Sepmag Q Series – Glass Bottle Magnetic Bead Separator
Choose Sepmag Q when your manufacturing process uses glass vessels.
Sepmag Q systems are designed for liter-scale magnetic bead separation in GMP manufacturing, with high product recovery, reproducible batch processing and real-time separation monitoring as standard.
Sepmag N — For Plastic and Single-Use Vessels
Choose Sepmag N when your manufacturing process uses plastic or single-use vessels.
Sepmag N systems are designed for GMP and cleanroom manufacturing where plastic or single-use vessels, flexible process integration and real-time separation monitoring are required.
Need a Non-Standard Configuration?
The correct separator depends not only on nominal volume, but also on vessel diameter, geometry and actual working volume.
For non-standard vessels, larger volumes or specific manufacturing requirements, Sepmag can develop a customized configuration.
What You Gain in Large Volume Magnetic Bead Separation
Protect Product Recovery
At production scale, even a small percentage of material loss can have a significant impact on yield and cost per batch.
Controlled magnetic bead collection helps minimize bead and target loss during separation, protecting valuable product.
Improve Batch-to-Batch Consistency
Maintain reproducible magnetic separation conditions across production batches.
Real-time monitoring verifies how every separation develops, providing objective evidence that the process follows the expected behavior.
Know When Separation Is Complete
There is no universal magnetic separation time.
Real-time monitoring generates a separation curve for every batch and allows the process endpoint to be objectively defined.
This helps avoid:
- Stopping too early, which can cause bead and product loss
- Waiting too long, which adds unnecessary process time
Detect Process Deviations
Changes in separation kinetics can reveal changes in beads, buffers, concentration or other process conditions.
Comparing the actual separation curve with expected behavior makes these deviations visible and supports faster investigation.
Reduce Bead Aggregation
Controlled bead movement minimizes excessive bead compaction during separation.
This facilitates subsequent resuspension and helps maintain consistent downstream processing.
Scale with Less Process Redevelopment
Transfer magnetic bead separation from process development to GMP manufacturing under controlled and measurable conditions.
A characterized separation process is easier to transfer, compare and validate than one based only on fixed separation times or visual judgement.
Real-Time Magnetic Separation Monitoring Is Standard
Every Sepmag Q and N system includes real-time separation monitoring as a standard capability.
The complete magnetic bead separation process is continuously measured from the start of separation until the defined endpoint is reached.
This allows Production and QA teams to:
- Monitor separation kinetics
- Define and confirm the endpoint
- Compare batches against a reference process
- Detect process deviations
- Investigate abnormal separation behavior
- Maintain objective separation records
- Support process characterization and validation
Sepmag monitoring software is 21 CFR Part 11 ready, supporting data management in regulated manufacturing environments.
Instead of knowing only how long the separator was running, you know how the magnetic beads actually behaved during separation.
Designed for GMP Manufacturing Integration
Sepmag Q and N large volume magnetic bead separators can be integrated into manual, semi-automated and automated production workflows.
Depending on the process, systems can be configured to work with:
- Pumps
- Valves
- Mixing systems
- PLC or external automation
- Vessel handling equipment
Sepmag Roller
Supports vessel rotation and mixing during the process.
Sepmag Elevator Desk
Facilitates loading, unloading and positioning of large production vessels.
Sepmag can work with the user or automation integrator to define the appropriate production configuration.
Large Volume Magnetic Bead Separation Applications
Sepmag Q and N systems are designed for production-scale magnetic bead processes including:
- DNA and RNA purification
- Protein and antibody purification
- Diagnostic reagent manufacturing
- Cell-related processes
- Magnetic bead manufacturing
- Other magnetic bead-based bioprocesses
Clients
Trusted by leading life science companies:
Frequently Asked Questions
What is a large volume magnetic bead separator?
A large volume magnetic bead separator is designed to perform magnetic bead separation at liter-scale volumes used in pilot and manufacturing processes. Sepmag Q and N systems cover standard production configurations up to 20 L, with customized solutions available for other requirements.
What is the difference between Sepmag Q and Sepmag N?
Sepmag Q is designed for glass vessels. Sepmag N is designed for plastic and single-use vessels. Both provide reproducible large volume magnetic bead separation with real-time monitoring.
How do I select the correct Sepmag Q or N model?
Select the model according to your vessel type, vessel dimensions and actual working volume. Sepmag can evaluate the process vessel to identify the appropriate separator configuration.
Is real-time monitoring included with Sepmag Q and N systems?
Yes. Real-time separation monitoring is a standard part of Sepmag Q and N systems. It provides separation curves, objective endpoint determination, batch comparison and process records.
Define Your Manufacturing Configuration
Tell us your:
Vessel type → vessel dimensions → working volume → magnetic beads → batch requirements → automation needs
We will help you identify the appropriate Sepmag system for your production process.
