The ability to extract high quality DNA and RNA is essential for expanding our understanding of molecular pathways, and has become particularly important with the advent of next-generation sequencing methods. As the sequencing technologies have advanced in the past decade, so have the strategies for DNA and RNA purification. Magnetic nucleic purification using superparamagnetic beads is more specific than traditional column-based separation methods, and can decrease isolation time, increase throughput, enable automation, and expand options for point-of-care diagnosis.

We have prepared this Magnetic DNA Purification Guide to help you gain a deeper understanding of the process, familiarize yourself with the tools available, and look forward to future possibilities.

In this guide you will find information about:

  • The history and theory of nucleic acid purification methods
  • Superparamagnetic particle coatings and surface chemicals for nucleic acid capture.   
  • The magnetic separation process and advanced separation systems
  • Five examples of magnetic DNA and RNA isolation in recent research
  • Potential applications for magnetic nucleic acid purification including lab-on-a-chip and point-of-care diagnostics

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