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How the scaling-up of Magnetic Bead Separation process may increase profitability?

The main consumers of magnetic beads are In Vitro Diagnostic (IVD) companies who utilize these materials for their kits. Since some of these companies are highly successful, as they obviously need to cope with higher demand for their kits by increasing production in a magnetic separation rack.

Download our Free Guide on Biomagnetic Separation Scale-up HERE.

This post is about Magnetic Bead Separation with a magnetic separation rack, and how to scale-up this process. If you are interested in this topic, download our free eBook The Basic Guide to Scale-up Magnetic Bead Separation Processes:

How can we increase production in a magnetic separation rack?

One way of increasing production of Magnetic Bead Separation processes is to maintain the working volume, but increase the number of lots. Doing this would require increasing the number of highly skilled workers needed to perform the separations. In addition, strict quality control would need to be enacted to make sure that each lot falls within an acceptable range of functionality and yield.

A better way of increasing production of Magnetic Bead Separation processes is to increase the lot volume. Increasing lot volumes allows companies to maintain labor and QC costs, while simultaneously decreasing the cost per unit of materials, thus maintaining or decreasing the overall cost of producing the IVD kits.

Limitations of increasing lot volume

The main limitation of increasing lot volume is the difficulty in keeping the working conditions and variables constant. In classic magnetic separators, the magnetic force changes as the volume changes. This means that conditions validated at small volumes cannot be automatically translated or reproduced at larger volumes. Thus, the advantages to scaling up (i.e. decreased cost of materials and workforce) are essentially lost because of the extra cost involved in validating the conditions at the new production volumes.

The use of advanced Magnetic Bead Separation systems that use homogeneous conditions, however, makes scaling up a straightforward process since the same magnetic force can be used at any volume. SEPMAG systems allow manufacturers to process lots up to tens of liters with the exact same validated conditions as the initial small lot volumes (typically several milliliters). Using homogeneous Magnetic Bead Separation systems, manufacturers can enjoy the cost reduction benefits of scaling up to large volume batches along with fulfilling increased demand, thus increasing the profitability of their product.

Don’t forget to check these posts from our blog in order to get a deeper insight into the scaling-up of Magnetic Bead Separation processes:

Check to access to FREE eBooks on the subject, or contact us. We will be glad to help you to achieve an efficient magnetic bead separation process!

magnetic separation rack

Lluis M. Martínez | SEPMAG Chief Scientific Officer

Founder of SEPMAG, Lluis holds a PhD in Magnetic Materials by the UAB. He has conducted research at German and Spanish academic institutions. Having worked in companies in Ireland, USA and Spain, he has more than 20 years of experience applying magnetic materials and sensors to industrial products and processes. He has filed several international patents on the field and co-authored more than 20 scientific papers, most of them on the subject of magnetic particle movement.

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