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Validation of biomagnetic separation processes

5 Reasons to Start using Homogeneous Magnetic Bead Separation

It is clear that homogenous Magnetic Bead Separation devices such as Sepmag are superior over the traditional methods of Magnetic Bead Separation. Biotech companies and industries that utilize IVD kits on a regular basis trust that the products they use are consistently reliable and result in reproducible data.

Companies that produce biotech products such as IVD kits are interested in decreasing cost of production, time of production and amount of manpower utilized. In order to assure consistency and reliability, it is important to establish a Standard Operating Procedure using protocols that can be followed precisely and checked at every point along the way.

Free PDF guide:  "Validation of Magnetic Bead Separation Processes" 

Traditional biomagnetic separation processes fail companies that produce these kits in several ways:

  1. Lot to lot quality is not consistent
  2. Processes are not readily scalable
  3. Processes cannot be readily monitored
  4. Often additional steps need to be taken to salvage aggregated beads
  5. Yields are not consistent between batches

When using homogenous Magnetic Bead Separation, however, companies are able to reproducibly create a quality product that is consistent from lot to lot. Homogenous Magnetic Bead Separation systems such as Sepmag generates a magnetic field that is the same everywhere in the vessel so that all beads experience the same magnetic force no matter how far they are from the magnet. Because of this unique feature, beads experience little to no aggregation and therefore require much less ‘hands on’ recovery (i.e. resuspension and sonication techniques) than beads produced by standard Magnetic Bead Separation devices.

Additional time exposed to the magnetic forces is also not necessary in order to recover beads farther from the magnet as so often happens with standard devices. Instead, yields are predictable and reliable and batches can be monitored in real time for deviation from a standard curve. Monitoring alone saves resources since scientists can detect any sort of anomaly immediately and adjust the process if necessary before it is too late. Homogenous Magnetic Bead Separation systems are clearly the wave of the future.

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Lluis M. Martínez | SEPMAG Chief Scientific Officer

Founder of SEPMAG, Lluis holds a PhD in Magnetic Materials by the UAB. He has conducted research at German and Spanish academic institutions. Having worked in companies in Ireland, USA and Spain, he has more than 20 years of experience applying magnetic materials and sensors to industrial products and processes. He has filed several international patents on the field and co-authored more than 20 scientific papers, most of them on the subject of magnetic particle movement.

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