Standardization, Scalability, and Quality Assurance
Establishing standard operating procedures (SOPs) for magnetic bead separation in large volumes is imperative for efficiently producing magnetic bead-based products at any scale. Traditional magnetic separators commonly used in research and development (R&D) laboratories lack standardized separation conditions due to the inherent variability in magnetic force with distance, rendering the replication of processes at larger volumes practically impossible. The dynamic nature of magnetic force, which is inversely proportional to distance squared, means that separation conditions change as soon as the vessel diameter is altered. The properties of magnetic forces make it challenging to maintain consistency in separation processes. Moreover, the option of increasing production by replicating small-volume processes is not feasible due to the high costs associated with validating multiple individual batches and ensuring their compliance with specifications.